Nature Communications (Sep 2021)
Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
- Nathan F. Schachter,
- Jessica R. Adams,
- Patryk Skowron,
- Katelyn. J. Kozma,
- Christian A. Lee,
- Nandini Raghuram,
- Joanna Yang,
- Amanda J. Loch,
- Wei Wang,
- Aaron Kucharczuk,
- Katherine L. Wright,
- Rita M. Quintana,
- Yeji An,
- Daniel Dotzko,
- Jennifer L. Gorman,
- Daria Wojtal,
- Juhi S. Shah,
- Paul Leon-Gomez,
- Giovanna Pellecchia,
- Adam J. Dupuy,
- Charles M. Perou,
- Ittai Ben-Porath,
- Rotem Karni,
- Eldad Zacksenhaus,
- Jim R. Woodgett,
- Susan J. Done,
- Livia Garzia,
- A. Sorana Morrissy,
- Jüri Reimand,
- Michael D. Taylor,
- Sean E. Egan
Affiliations
- Nathan F. Schachter
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Jessica R. Adams
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Patryk Skowron
- Program in Developmental & Stem Cell Biology, The Hospital for Sick Children
- Katelyn. J. Kozma
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Christian A. Lee
- Computational Biology Program, Ontario Institute for Cancer Research
- Nandini Raghuram
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Joanna Yang
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Amanda J. Loch
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Wei Wang
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Aaron Kucharczuk
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Katherine L. Wright
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Rita M. Quintana
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Yeji An
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Daniel Dotzko
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Jennifer L. Gorman
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Daria Wojtal
- Department of Molecular Genetics, University of Toronto
- Juhi S. Shah
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Paul Leon-Gomez
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- Giovanna Pellecchia
- The Center for Applied Genomics, The Hospital for Sick Children
- Adam J. Dupuy
- Department of Pathology, Carver College of Medicine, The University of Iowa
- Charles M. Perou
- Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina
- Ittai Ben-Porath
- Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School
- Rotem Karni
- Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School
- Eldad Zacksenhaus
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Jim R. Woodgett
- Department of Medical Biophysics, University of Toronto
- Susan J. Done
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Livia Garzia
- Program in Developmental & Stem Cell Biology, The Hospital for Sick Children
- A. Sorana Morrissy
- Program in Developmental & Stem Cell Biology, The Hospital for Sick Children
- Jüri Reimand
- Department of Molecular Genetics, University of Toronto
- Michael D. Taylor
- Program in Developmental & Stem Cell Biology, The Hospital for Sick Children
- Sean E. Egan
- Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-021-25467-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.
