Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply

Chao Liu; Tianxu Han; David L. Stachura; Huawei Wang; Boris L. Vaisman; Jungsu Kim; Richard L. Klemke; Alan T. Remaley; Tariq M. Rana; David Traver; Yury I. Miller

doi:10.1038/s41467-018-03775-y

Nature Communications (Apr 2018)

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply

Chao Liu,
Tianxu Han,
David L. Stachura,
Huawei Wang,
Boris L. Vaisman,
Jungsu Kim,
Richard L. Klemke,
Alan T. Remaley,
Tariq M. Rana,
David Traver,
Yury I. Miller

Affiliations

Chao Liu: Department of Medicine, University of California, San Diego
Tianxu Han: Department of Pediatrics, University of California, San Diego
David L. Stachura: Department of Cellular and Molecular Medicine, University of California, San Diego
Huawei Wang: Department of Pathology, University of California, San Diego
Boris L. Vaisman: Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung, and Blood Institute
Jungsu Kim: Department of Medicine, University of California, San Diego
Richard L. Klemke: Department of Pathology, University of California, San Diego
Alan T. Remaley: Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung, and Blood Institute
Tariq M. Rana: Department of Pediatrics, University of California, San Diego
David Traver: Department of Cellular and Molecular Medicine, University of California, San Diego
Yury I. Miller: Department of Medicine, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-018-03775-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Lipoprotein lipase (LPL) hydrolyzes triglycerides to supply free fatty acids (FFAs) to muscle for energy and adipocytes for storage. Here, the authors demonstrate that Lpl and its product, the FFA docosahexaenoic acid (DHA) are required for haematopoietic stem progenitor cell expansion during zebrafish embryogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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