PREDICTING THE EFFECTIVENESS OF HUMAN CHORIONIC GONADOTROPIN IN THE TREATMENT OF INFERTILITY AND HYPOGONADISM IN MEN

Abstract

Introduction. Most urologists and andrologists for the initial therapy of hypogonadism use human chorionic gonadotropin (HCG), but not always the results of treatment satisfy specialists.Objective is to study the effectiveness of infertility and hypogonadism treatment in men with HCG therapy depending on the level of testosterone-estradiol index.Materials and methods. HCG treatment of 60 male patients with infertility and hypogonadism was carried out. Prior to the start of therapy, all patients underwent 3-day HCG test, with the determination of testosterone and estradiol levels. The analysis of semen indices was carried out. Results. Improvement of semen indices was registered only in those patients, in which during the functional HCG test the level of testosterone increased to a greater extent than estradiol level, that is, an increase in the testosterone-estradiol index was recorded.Conclusion. In order to predict the effectiveness of the upcoming treatment with HCG drugs, it is necessary to conduct a test with the definition of testosterone-estradiol index, which allows to identify patients in whom this type of therapy will lead to improvement of the main semen indices.

Keywords

• infertility
• hypogonadism
• human chorionic gonadotropin
• functional test
• testosterone-estradiol index