Role of intercellular adhesion molecules in the development of the endometrial neoplasias

Abstract

In article the processes of intercellular adhesion in unchanged proliferating endometrium, hyperplasia and adenocarcinoma are surveyed. Expression E-kadherin, β-katenin and claudin-1 at different stages of epithelial neoplastic transformation of endometrium by immunohistochemical method had been estimated. The role of key proteins Wnt-signaling pathway and Claudine-1 in the development of malignant transformation of glandular cells of endometrium was established.

Keywords

• эндометрий
• молекулы межклеточной адгезии
• E-кадгерин
• β-катенин
• клаудин-1