Communications Biology (Jan 2022)

Generative adversarial network enables rapid and robust fluorescence lifetime image analysis in live cells

  • Yuan-I Chen,
  • Yin-Jui Chang,
  • Shih-Chu Liao,
  • Trung Duc Nguyen,
  • Jianchen Yang,
  • Yu-An Kuo,
  • Soonwoo Hong,
  • Yen-Liang Liu,
  • H. Grady Rylander,
  • Samantha R. Santacruz,
  • Thomas E. Yankeelov,
  • Hsin-Chih Yeh

DOI
https://doi.org/10.1038/s42003-021-02938-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 11

Abstract

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In this study, Chen et al. introduced a new deep learning-based method termed flimGANE to rapidly generate accurate and high-quality FLIM images even in the photon-starved conditions. flimGANE is particularly useful in fundamental biological research and clinical applications.