Role of COX-2 in the regulation of the metastatic potential of human breast tumor cells

Abstract

The expression of СOX-2, VEGF, VEGFR-1, VEGFR-2, VEGFR-3, EGFR, endoglin (СD105), and IL-6 was analyzed in the human breast tumor cells having a varying metastatic potential. The role of these factors in the regulation of the metastatic potential of breast cancer cells, as well as that of COX-2 in the regulation of metastatic processes at the cellular level were examined. The potential capacity of human breast tumor cells to elaborate factors that stimulate tumor growth, angiogenesis, and metastasis was evaluated.

Keywords

• breast cancer
• cox-2
• vegf
• vegfr-1
• vegfr-2
• vegfr-3
• egfr
• endoglin (сd105)
• il-6
• angiogenesis
• metastasis
• mcf-7
• bt-474
• and zr-75-1 human breast tumor cell lines
• therapeutic targets