Nature Communications (Jan 2022)
Latency reversal plus natural killer cells diminish HIV reservoir in vivo
- Jocelyn T. Kim,
- Tian-Hao Zhang,
- Camille Carmona,
- Bryanna Lee,
- Christopher S. Seet,
- Matthew Kostelny,
- Nisarg Shah,
- Hongying Chen,
- Kylie Farrell,
- Mohamed S. A. Soliman,
- Melanie Dimapasoc,
- Michelle Sinani,
- Kenia Yazmin Reyna Blanco,
- David Bojorquez,
- Hong Jiang,
- Yuan Shi,
- Yushen Du,
- Natalia L. Komarova,
- Dominik Wodarz,
- Paul A. Wender,
- Matthew D. Marsden,
- Ren Sun,
- Jerome A. Zack
Affiliations
- Jocelyn T. Kim
- Department of Medicine, Division of Infectious Diseases, University of California Los Angeles
- Tian-Hao Zhang
- Molecular Biology Institute, University of California Los Angeles
- Camille Carmona
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Bryanna Lee
- Department of Medicine, Division of Infectious Diseases, University of California Los Angeles
- Christopher S. Seet
- Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles
- Matthew Kostelny
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Nisarg Shah
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Hongying Chen
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Kylie Farrell
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Mohamed S. A. Soliman
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Melanie Dimapasoc
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Michelle Sinani
- Department of Medicine, Division of Infectious Diseases, University of California Los Angeles
- Kenia Yazmin Reyna Blanco
- Department of Medicine, Division of Infectious Diseases, University of California Los Angeles
- David Bojorquez
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Hong Jiang
- Department of Molecular and Medical Pharmacology, University of California
- Yuan Shi
- Department of Molecular and Medical Pharmacology, University of California
- Yushen Du
- Department of Molecular and Medical Pharmacology, University of California
- Natalia L. Komarova
- Department of Mathematics, University of California, Irvine
- Dominik Wodarz
- Department of Population Health and Disease Prevention, Program in Public Health Susan and Henry Samueli College of Health Sciences, University of California, Irvine
- Paul A. Wender
- Department of Chemistry and Department of Chemical and Systems Biology, Stanford University
- Matthew D. Marsden
- Department of Microbiology and Molecular Genetics and Department of Medicine, Division of Infectious Diseases, School of Medicine, University of California, Irvine
- Ren Sun
- Department of Molecular and Medical Pharmacology, University of California
- Jerome A. Zack
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- DOI
- https://doi.org/10.1038/s41467-021-27647-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Here, Kim et al. describe a new kick and kill strategy utilizing a single administration of a protein kinase C modulator and latency reversing agent in combination with injections of allogeneic peripheral blood natural killer cells diminishes the HIV reservoir in HIV-infected humanized mice.
