Dataset of NMR-spectra pyrrolyl- and indolylazines and evidence of their ability to induce heat shock genes expression in human neurons
Elizaveta A. Dutysheva,
Irina A. Utepova,
Maria A. Trestsova,
Alexander S. Anisimov,
Valery N. Charushin,
Oleg N. Chupakhin,
Boris A. Margulis,
Irina V. Guzhova,
Vladimir F. Lazarev
Affiliations
Elizaveta A. Dutysheva
Russian Academy of Sciences, Institute of Cytology, St. Petersburg 194064, Russia
Irina A. Utepova
Ural Federal University, Ekaterinburg 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia
Maria A. Trestsova
Ural Federal University, Ekaterinburg 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia
Alexander S. Anisimov
Russian Academy of Sciences, Institute of Cytology, St. Petersburg 194064, Russia
Valery N. Charushin
Ural Federal University, Ekaterinburg 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia
Oleg N. Chupakhin
Ural Federal University, Ekaterinburg 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia
Boris A. Margulis
Russian Academy of Sciences, Institute of Cytology, St. Petersburg 194064, Russia
Irina V. Guzhova
Russian Academy of Sciences, Institute of Cytology, St. Petersburg 194064, Russia
Vladimir F. Lazarev
Russian Academy of Sciences, Institute of Cytology, St. Petersburg 194064, Russia; Corresponding author.
These data are related to our previous paper “Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer's disease” (Dutysheva et al., 2021), in which we demonstrate neuroprotective abilities of pyrrolyl- and indolylazines in a cell model of Alzheimer's disease. Using a novel procedure of photocatalysis we have synthesized a group of new compounds. The current article presents nuclear magnetic resonance spectra including heteronuclear single quantum coherence spectra of chemicals synthesized by us. The effect of new compounds have on heat shock proteins genes expression in reprogrammed human neurons are presented. We also presented data that verify neuronal phenotype of reprogrammed cells.
