Nature Communications (Dec 2020)
Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice
- Zhi Zhang,
- Fernando M. C. V. Reis,
- Yanlin He,
- Jae W. Park,
- Johnathon R. DiVittorio,
- Nilla Sivakumar,
- J. Edward van Veen,
- Sandra Maesta-Pereira,
- Michael Shum,
- India Nichols,
- Megan G. Massa,
- Shawn Anderson,
- Ketema Paul,
- Marc Liesa,
- Olujimi A. Ajijola,
- Yong Xu,
- Avishek Adhikari,
- Stephanie M. Correa
Affiliations
- Zhi Zhang
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Fernando M. C. V. Reis
- Department of Psychology, University of California Los Angeles
- Yanlin He
- USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Jae W. Park
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Johnathon R. DiVittorio
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Nilla Sivakumar
- Department of Integrative Biology and Physiology, University of California Los Angeles
- J. Edward van Veen
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Sandra Maesta-Pereira
- Department of Psychology, University of California Los Angeles
- Michael Shum
- Division of Endocrinology, Department of Medicine, David Geffen School of Medicine
- India Nichols
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Megan G. Massa
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Shawn Anderson
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Ketema Paul
- Department of Integrative Biology and Physiology, University of California Los Angeles
- Marc Liesa
- Division of Endocrinology, Department of Medicine, David Geffen School of Medicine
- Olujimi A. Ajijola
- UCLA Cardiac Arrhythmia Center, Department of Medicine, David Geffen School of Medicine
- Yong Xu
- USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
- Avishek Adhikari
- Brain Research Institute, University of California Los Angeles
- Stephanie M. Correa
- Department of Integrative Biology and Physiology, University of California Los Angeles
- DOI
- https://doi.org/10.1038/s41467-020-20050-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Torpor is a state of reduced metabolism and body temperature that conserves energy when food is scarce. Here the authors show that estrogen-sensitive neurons in the hypothalamus regulate torpor in mice, maintaining torpor in both sexes but initiating torpor and regulating core temperature differentially across sex.
