Asymmetric desymmetrization of meso-diols by C2-symmetric chiral 4-pyrrolidinopyridines

Abstract

In this work we developed C2-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective acylation.

Keywords

• acylation
• desymmetrization
• hydrogen bond
• meso-diol
• nucleophilic catalyst
• organocatalysis