Nature Communications (Mar 2023)
Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease
- Bethany N. Radford,
- Xiang Zhao,
- Tali Glazer,
- Malcolm Eaton,
- Danielle Blackwell,
- Shuhiba Mohammad,
- Lucas Daniel Lo Vercio,
- Jay Devine,
- Tali Shalom-Barak,
- Benedikt Hallgrimsson,
- James C. Cross,
- Henry M. Sucov,
- Yaacov Barak,
- Wendy Dean,
- Myriam Hemberger
Affiliations
- Bethany N. Radford
- Dept. of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Xiang Zhao
- Dept. of Cell Biology and Anatomy, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Tali Glazer
- Dept. of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Malcolm Eaton
- Dept. of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Danielle Blackwell
- Dept. of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Shuhiba Mohammad
- Dept. of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Lucas Daniel Lo Vercio
- Dept. of Cell Biology and Anatomy, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Jay Devine
- Dept. of Cell Biology and Anatomy, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Tali Shalom-Barak
- Magee-Women’s Research Institute, Dept. of Obstetrics/Gynecology and Reproductive Sciences, University of Pittsburgh
- Benedikt Hallgrimsson
- Dept. of Cell Biology and Anatomy, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- James C. Cross
- Dept. of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Henry M. Sucov
- Dept. of Regenerative Medicine and Cell Biology, Division of Cardiology, Dept. of Medicine, Medical University of South Carolina
- Yaacov Barak
- Magee-Women’s Research Institute, Dept. of Obstetrics/Gynecology and Reproductive Sciences, University of Pittsburgh
- Wendy Dean
- Dept. of Cell Biology and Anatomy, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- Myriam Hemberger
- Dept. of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary
- DOI
- https://doi.org/10.1038/s41467-023-36740-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Placental dysfunction can affect heart development, but the prevalence of this causality has not been well established. Here, the authors use mouse genetic tools to show that the placenta may constitute a significant source of congenital heart defects.
