Nature Communications (Nov 2022)
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration
- Chujiao Lin,
- Qiyuan Yang,
- Dongsheng Guo,
- Jun Xie,
- Yeon-Suk Yang,
- Sachin Chaugule,
- Ngoc DeSouza,
- Won-Taek Oh,
- Rui Li,
- Zhihao Chen,
- Aijaz A. John,
- Qiang Qiu,
- Lihua Julie Zhu,
- Matthew B. Greenblatt,
- Sankar Ghosh,
- Shaoguang Li,
- Guangping Gao,
- Cole Haynes,
- Charles P. Emerson,
- Jae-Hyuck Shim
Affiliations
- Chujiao Lin
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Qiyuan Yang
- Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School
- Dongsheng Guo
- Department of Neurology, UMass Chan Medical School
- Jun Xie
- Horae Gene Therapy Center, UMass Chan Medical School
- Yeon-Suk Yang
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Sachin Chaugule
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Ngoc DeSouza
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Won-Taek Oh
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Rui Li
- Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School
- Zhihao Chen
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Aijaz A. John
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Qiang Qiu
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Lihua Julie Zhu
- Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School
- Matthew B. Greenblatt
- Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University
- Sankar Ghosh
- Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons
- Shaoguang Li
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- Guangping Gao
- Horae Gene Therapy Center, UMass Chan Medical School
- Cole Haynes
- Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School
- Charles P. Emerson
- Department of Neurology, UMass Chan Medical School
- Jae-Hyuck Shim
- Department of Medicine/Division of Rheumatology, UMass Chan Medical School
- DOI
- https://doi.org/10.1038/s41467-022-34694-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Skeletal progenitors provide a reservoir for bone-forming osteoblasts. However, the major energy source for their osteogenesis remains unresolved. Here, the authors demonstrate that ESCIT-mediated regulation of mitochondrial metabolism is required for osteogenesis.
