EUCAST v.12.0 Review Focused on Changes

Abstract

Clinical and Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoint tables are commonly used as guidelines for the interpretation of antimicrobial susceptibility testing results. These are updated annually to reflect new and revised antimicrobial susceptibility breakpoints. EUCAST v.12.0, which was published in January 2022, presents updated meropenem-vaborbactam breakpoints for Enterobacterales and Pseudomonas aeruginosa. It also suggests new breakpoints of susceptibility to various antibiotics for Vibrio spp. Flow charts were updated for Streptococcus pneumoniae and Haemophilus influenzae, and the breakpoints for anaerobic bacteria were divided according to each species. Furthermore, recommendations were made for cases without antimicrobial susceptibility testing breakpoints and links to several rationale and guidance documents were provided for technical convenience.

Keywords

• antimicrobial susceptibility testing
• breakpoint
• eucast v.12.0