A comprehensive review of Sjögren's syndrome: Classification criteria, risk factors, and signaling pathways
Ting Zhao,
Runrun Zhang,
Zhaofu Li,
Dongdong Qin,
Xinchang Wang
Affiliations
Ting Zhao
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming, 650500, China; The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, China
Runrun Zhang
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, China
Zhaofu Li
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming, 650500, China; Corresponding author.
Dongdong Qin
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming, 650500, China; The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, China; Corresponding author. Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Xinchang Wang
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, China; Corresponding author.
Sjögren's syndrome (SS) is a chronic autoimmune disease that affects the exocrine glands and may lead to a range of systemic symptoms that impact various organs. Both innate and adaptive immune pathways might trigger the disease. Studying the signaling pathways underlying SS is crucial for enhancing diagnostic and therapeutic effectiveness. SS poses an ongoing challenge for medical professionals owing to the limited therapeutic options available. This review offers a comprehensive understanding of the intricate nature of SS, encompassing disease classification criteria, risk factors, and signaling pathways in immunity and inflammation. The advancements summarized herein have the potential to spark new avenues of research into SS.
