Intravascular large B-cell lymphoma with respiratory failure diagnosed by random skin biopsy: A case report

Haruka Fujioka; Kei Nakashima; Yuka Uesugi; Miki Nyui; Naoki Inoshima; Jun Hayashi; Michinori Yoshimi; Miho Katsumata; Masahiro Masuzawa; Hayato Usami; Akane Ito; Rikako Tabata; Kosei Matsue

Respiratory Medicine Case Reports (Jan 2024)

Intravascular large B-cell lymphoma with respiratory failure diagnosed by random skin biopsy: A case report

Haruka Fujioka,
Kei Nakashima,
Yuka Uesugi,
Miki Nyui,
Naoki Inoshima,
Jun Hayashi,
Michinori Yoshimi,
Miho Katsumata,
Masahiro Masuzawa,
Hayato Usami,
Akane Ito,
Rikako Tabata,
Kosei Matsue

Affiliations

Haruka Fujioka: Department of Pulmonology, Kameda Medical Center, Chiba, Japan
Kei Nakashima: Department of Pulmonology, Kameda Medical Center, Chiba, Japan; Corresponding author. Department of Pulmonology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan.
Yuka Uesugi: Department of Hematology and Oncology, Kameda Medical Center, Chiba, Japan; Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
Miki Nyui: Department of Pathology, Kameda Medical Center, Chiba, Japan
Naoki Inoshima: Department of Pulmonology, Kameda Medical Center, Chiba, Japan
Jun Hayashi: Department of Pulmonology, Kameda Medical Center, Chiba, Japan
Michinori Yoshimi: Department of Pulmonology, Kameda Medical Center, Chiba, Japan
Miho Katsumata: Department of Diabetes and Endocrinology, Kameda Medical Center, Chiba, Japan; Department of Diabetes and Endocrinology, Nara Medical University, Nara, Japan
Masahiro Masuzawa: Department of Diabetes and Endocrinology, Kameda Medical Center, Chiba, Japan
Hayato Usami: Department of General Medicine, Kameda Medical Center, Chiba, Japan
Akane Ito: Department of General Medicine, Kameda Medical Center, Chiba, Japan
Rikako Tabata: Department of Hematology and Oncology, Kameda Medical Center, Chiba, Japan
Kosei Matsue: Department of Hematology and Oncology, Kameda Medical Center, Chiba, Japan

Journal volume & issue: Vol. 52
p. 102115

Abstract

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Intravascular large B-cell lymphoma (IVLBCL) typically involves nonspecific symptoms that complicate diagnosis. This report discusses the case of a 70-year-old man, who presented with dyspnea, fatigue, and weight loss that evolved into severe respiratory failure, diagnosed with IVLBCL via random skin biopsy. The initial improvement in respiratory symptoms was followed by coronavirus disease. Response to steroid therapy and elevated lactate dehydrogenase levels suggested IVLBCL, confirmed by a random skin biopsy. The combination chemotherapy of rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisolone improved the respiratory condition. This case highlights the diagnostic challenges associated with IVLBCL and the crucial role of random skin biopsy.

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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Abstract

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