International Journal of Nanomedicine (Sep 2021)

Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment

  • Zhang W,
  • Hu E,
  • Wang Y,
  • Miao S,
  • Liu Y,
  • Hu III Y,
  • Liu J,
  • Xu B,
  • Chen D,
  • Shen Y

Journal volume & issue
Vol. Volume 16
pp. 6141 – 6156

Abstract

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Wenli Zhang,1,* Enshi Hu,1,* Yajie Wang,1,* Si Miao,1 Yanyan Liu,1 Yumin Hu III,1 Ji Liu,1 Bohui Xu,2 Daquan Chen,3 Yan Shen1 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 2School of Pharmacy, Nantong University, Nantong, 226001, People’s Republic of China; 3School of Pharmacy, Yantai University, State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, 264005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Shen; Daquan Chen Tel +86-25-83271305; +86-535-6706021Email [email protected]; [email protected]: At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiotic delivery system to improve drug delivery behavior, in order to delay the generation of bacterial drug resistance. In recent years, with the continuous development of nanotechnology, various types of nanocarriers that respond to the infection microenvironment, targeting specific bacterial targets, and targeting infected cells, and so on, are gradually being used in the delivery of antibacterial agents to increase the concentration of drugs at the site of infection and reduce the side effects of drugs in normal tissues. Here, this article describes in detail the latest research progress on nanocarriers for antimicrobial, and commonly used targeted antimicrobial strategies. The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected.Keywords: nanocarriers, antimicrobial, drug delivery, targeting strategies

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