Role of Extracellular Vesicles Derived Non-coding RNAs in Diabetic Kidney Disease

Abstract

Diabetic kidney disease (DKD), a metabolic related syndrome characterized by abnormal glomerular filtration rate (GFR), proteinuria and renal microangiopathy, is one of the most common form of chronic kidney diseases (CKD), whereas extracellular vesicles (EVs) have been recently evidenced as a novel cell communication player in DKD occurrence and progress via releasing various of bioactive molecules, including proteins, lipids and especially RNA, among which noncoding RNAs (including miRNAs, lncRNAs and circRNAs) are the major regulators. In current review, we summarized the mechanistic role of EVs in DKD according to biology function classifications, including inflammation and oxidative stress, epithelial–mesenchymal transition (EMT), cell death and extracellular matrix (ECM) deposition. Furthermore, potential clinical applications based on these non-coding RNA have also been reviewed, thereby expecting possible therapeutic insights in clinical practice.