Protective effect of α-mangostin on retinal light damage in mice

Abstract

AIM: To discuss the protective effect of α-mangostin on retinal light damage in mice.METHODS: Totally 30 Balb/c mice, aged 6～8wk, were randomly divided into the control group, light-exposure group and α-mangostin group. Every group contained 10 mice. Mice of α-mangostin group were treated with alpha-mangostin at the dose of 30mg/(kg·d)body weight by intragastric administration daily for 7d, and then exposed to white light at the 5thd. The light-exposure group and α-mangostin group were exposed to 5 000±200lx white light-emmiting diodes(LEDs)for continuously 1h to establish the mice model of retinal light damage. Flash-electroretinograme was recorded 72h after light exposure. The changes in retinal morphology of mice were observed by light microscopy. Retinas were extracted to detect the malondialdhyde(MDA)content change of the retinal homogenate.RESULTS: Flash-electroretinogram(F-ERG)showed that retinal dysfunction was less severe in α-mangostin group than in light-exposure group(PPPCONCLUSION: α-mangostin inhibits lipid peroxidation induced by light damage and protect retina against light damage.

Keywords

• retinal light damage
• α-mangostin
• oxidative stress
• electroretinogram
• outer nuclear layer
• malondialdhyde