PLoS ONE (2013-01-01)

Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.

  • Didier K Ekouevi,
  • Eric Balestre,
  • Patrick A Coffie,
  • Daouda Minta,
  • Eugene Messou,
  • Adrien Sawadogo,
  • Albert Minga,
  • Papa Salif Sow,
  • Emmanuel Bissagnene,
  • Serge P Eholie,
  • Geoffrey S Gottlieb,
  • François Dabis,
  • IeDEA West Africa collaboration,
  • Djimon Marcel Zannou,
  • Carin Ahouada,
  • Jocelyn Akakpo,
  • Christelle Ahomadegbé,
  • Jules Bashi,
  • Alice Gougounon-Houéto,
  • Angèle Azon-Kouanou,
  • Fabien Houngbé,
  • Sikiratou Koumakpaï,
  • Florence Alihonou,
  • Marcelline d'Almeida,
  • Irvine Hodonou,
  • Ghislaine Hounhoui,
  • Gracien Sagbo,
  • Leïla Tossa-Bagnan,
  • Herman Adjide,
  • Joseph Drabo,
  • René Bognounou,
  • Arnaud Dienderé,
  • Eliezer Traore,
  • Lassane Zoungrana,
  • Béatrice Zerbo,
  • Adrien Bruno Sawadogo,
  • Jacques Zoungrana,
  • Arsène Héma,
  • Ibrahim Soré,
  • Guillaume Bado,
  • Achille Tapsoba,
  • Diarra Yé,
  • Fla Kouéta,
  • Sylvie Ouedraogo,
  • Rasmata Ouédraogo,
  • William Hiembo,
  • Mady Gansonré,
  • Eugène Messou,
  • Joachim Charles Gnokoro,
  • Mamadou Koné,
  • Guillaume Martial Kouakou,
  • Clarisse Amani Bosse,
  • Kouakou Brou,
  • Achi Isidore Assi,
  • Henri Chenal,
  • Denise Hawerlander,
  • Franck Soppi,
  • Albert Minga,
  • Yao Abo,
  • Germain Bomisso,
  • Serge Paul Eholié,
  • Mensah Deborah Noelly Amego,
  • Viviane Andavi,
  • Zelica Diallo,
  • Frédéric Ello,
  • Aristophane Koffi Tanon,
  • Serge Olivier Koule,
  • Koffi Charles Anzan,
  • Calixte Guehi,
  • Edmond Addi Aka,
  • Koffi Ladji Issouf,
  • Jean-Claude Kouakou,
  • Marie-Sylvie N'gbeche,
  • Pety Touré,
  • Divine Avit-Edi,
  • Kouadio Kouakou,
  • Magloire Moh,
  • Valérie Andoblé Yao,
  • Madeleine Amorissani Folquet,
  • Marie-Evelyne Dainguy,
  • Cyrille Kouakou,
  • Véronique Tanoh Méa-Assande,
  • Gladys Oka-Berete,
  • Nathalie Zobo,
  • Patrick Acquah,
  • Marie-Berthe Kokora,
  • Tanoh François Eboua,
  • Marguerite Timité-Konan,
  • Lucrèce Diecket Ahoussou,
  • Julie Kebé Assouan,
  • Mabéa Flora Sami,
  • Clémence Kouadio,
  • Lorna Renner,
  • Bamenla Goka,
  • Jennifer Welbeck,
  • Adziri Sackey,
  • Seth Ntiri Owiafe,
  • Christian Wejse,
  • Zacarias José Da Silva,
  • Joao Paulo,
  • Amabelia Rodrigues,
  • David da Silva,
  • Candida Medina,
  • Ines Oliviera-Souto,
  • Lars Ostergaard,
  • Alex Laursen,
  • Morten Sodemann,
  • Peter Aaby,
  • Anders Fomsgaard,
  • Christian Erikstrup,
  • Jesper Eugen-Olsen,
  • Moussa Y Maïga,
  • Fatoumata Fofana Diakité,
  • Abdoulaye Kalle,
  • Drissa Katile,
  • Hamar Alassane Traore,
  • Daouda Minta,
  • Tidiani Cissé,
  • Mamadou Dembelé,
  • Mohammed Doumbia,
  • Mahamadou Fomba,
  • Assétou Soukho Kaya,
  • Abdoulaye M Traoré,
  • Hamady Traoré,
  • Amadou Abathina Toure,
  • Fatoumata Dicko,
  • Mariam Sylla,
  • Alima Berthé,
  • Hadizatou Coulibaly Traoré,
  • Anta Koïta,
  • Niaboula Koné,
  • Clémentine N'diaye,
  • Safiatou Touré Coulibaly,
  • Mamadou Traoré,
  • Naïchata Traoré,
  • Man Charurat,
  • Samuel Ajayi,
  • Stephen Dapiap,
  • Otu,
  • Festus Igbinoba,
  • Okwara Benson,
  • Clément Adebamowo,
  • Jesse James,
  • Obaseki,
  • Philip Osakede,
  • John Olasode,
  • Papa Salif Sow,
  • Bernard Diop,
  • Noël Magloire Manga,
  • Judicael Malick Tine,
  • Haby Signate Sy,
  • Abou Ba,
  • Aida Diagne,
  • Hélène Dior,
  • Malick Faye,
  • Ramatoulaye Diagne Gueye,
  • Aminata Diack Mbaye,
  • Akessiwe Patassi,
  • Awèrou Kotosso,
  • Benjamin Goilibe Kariyare,
  • Gafarou Gbadamassi,
  • Agbo Komi,
  • Kankoé Edem Mensah-Zukong,
  • Pinuwe Pakpame,
  • Annette Koko Lawson-Evi,
  • Yawo Atakouma,
  • Elom Takassi,
  • Améyo Djeha,
  • Ayoko Ephoévi-Gah,
  • Sherifa El-Hadj Djibril,
  • François Dabis,
  • Emmanuel Bissagnene,
  • Elise Arrivé,
  • Patrick Coffie,
  • Didier Ekouevi,
  • Antoine Jaquet,
  • Valériane Leroy,
  • Charlotte Lewden,
  • Annie Sasco,
  • Jean-Claude Azani,
  • Gérard Allou,
  • Eric Balestre,
  • Franck Bohossou,
  • Sophie Karcher,
  • Jules Mahan Gonsan,
  • Jérôme Le Carrou,
  • Séverin Lenaud,
  • Célestin Nchot,
  • Karen Malateste,
  • Amon Roseamonde Yao,
  • Bertine Siloué,
  • Gwenaelle Clouet,
  • Hugues Djetouan,
  • Alexandra Doring,
  • Adrienne Kouakou,
  • Elodie Rabourdin,
  • Jean Rivenc,
  • Xavier Anglaret,
  • Boubacar Ba,
  • Jean Bosco Essanin,
  • Andrea Ciaranello,
  • Sébastien Datté,
  • Sophie Desmonde,
  • Jean-Serge Elvis Diby,
  • Geoffrey S Gottlieb,
  • Apollinaire Gninlgninrin Horo,
  • Serge N'zoré Kangah,
  • Denis Malvy,
  • David Meless,
  • Aida Mounkaila-Harouna,
  • Camille Ndondoki,
  • Caroline Shiboski,
  • Rodolphe Thiébaut,
  • Pac-Ci,
  • Abidjan

DOI
https://doi.org/10.1371/journal.pone.0066135
Journal volume & issue
Vol. 8, no. 6
p. e66135

Abstract

Read online

HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA).We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region.Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm(3), IQR (83-247) among HIV-2 infected patients and 146 cells/mm(3), IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3) after 24 months on ART for HIV-2 patients and 169 cells/mm(3) for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3).This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.