Nature Communications (Nov 2018)
ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
- Andreia V. Pinho,
- Mathias Van Bulck,
- Lorraine Chantrill,
- Mehreen Arshi,
- Tatyana Sklyarova,
- David Herrmann,
- Claire Vennin,
- David Gallego-Ortega,
- Amanda Mawson,
- Marc Giry-Laterriere,
- Astrid Magenau,
- Gunther Leuckx,
- Luc Baeyens,
- Anthony J. Gill,
- Phoebe Phillips,
- Paul Timpson,
- Andrew V. Biankin,
- Jianmin Wu,
- Ilse Rooman
Affiliations
- Andreia V. Pinho
- Cancer Division, The Garvan Institute of Medical Research
- Mathias Van Bulck
- Oncology Research Centre, Vrije Universiteit Brussel
- Lorraine Chantrill
- Cancer Division, The Garvan Institute of Medical Research
- Mehreen Arshi
- Cancer Division, The Garvan Institute of Medical Research
- Tatyana Sklyarova
- Oncology Research Centre, Vrije Universiteit Brussel
- David Herrmann
- Cancer Division, The Garvan Institute of Medical Research
- Claire Vennin
- Cancer Division, The Garvan Institute of Medical Research
- David Gallego-Ortega
- Cancer Division, The Garvan Institute of Medical Research
- Amanda Mawson
- Cancer Division, The Garvan Institute of Medical Research
- Marc Giry-Laterriere
- Cancer Division, The Garvan Institute of Medical Research
- Astrid Magenau
- Cancer Division, The Garvan Institute of Medical Research
- Gunther Leuckx
- Beta cell Neogenesis Lab, Vrije Universiteit Brussel
- Luc Baeyens
- Beta cell Neogenesis Lab, Vrije Universiteit Brussel
- Anthony J. Gill
- Cancer Division, The Garvan Institute of Medical Research
- Phoebe Phillips
- Lowy Cancer Research Centre, University of New South Wales
- Paul Timpson
- Cancer Division, The Garvan Institute of Medical Research
- Andrew V. Biankin
- Australian Pancreatic Cancer Genome Initiative (APGI)
- Jianmin Wu
- Australian Pancreatic Cancer Genome Initiative (APGI)
- Ilse Rooman
- Australian Pancreatic Cancer Genome Initiative (APGI)
- DOI
- https://doi.org/10.1038/s41467-018-07497-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findings are relevant to PDAC patients, where ROBO expression correlates with survival outcomes.
