Nature Communications (Aug 2022)
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19
- Maik Pietzner,
- Robert Lorenz Chua,
- Eleanor Wheeler,
- Katharina Jechow,
- Julian D. S. Willett,
- Helena Radbruch,
- Saskia Trump,
- Bettina Heidecker,
- Hugo Zeberg,
- Frank L. Heppner,
- Roland Eils,
- Marcus A. Mall,
- J. Brent Richards,
- Leif-Erik Sander,
- Irina Lehmann,
- Sören Lukassen,
- Nicholas J. Wareham,
- Christian Conrad,
- Claudia Langenberg
Affiliations
- Maik Pietzner
- Computational Medicine, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Robert Lorenz Chua
- Center for Digital Health, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Eleanor Wheeler
- MRC Epidemiology Unit, University of Cambridge
- Katharina Jechow
- Center for Digital Health, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Julian D. S. Willett
- McGill Genome Centre, McGill University
- Helena Radbruch
- Department of Neuropathology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin
- Saskia Trump
- Molecular Epidemiology Unit, Center for Digital Health, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Bettina Heidecker
- Department of Cardiology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin
- Hugo Zeberg
- Max Planck Institute for Evolutionary Anthropology
- Frank L. Heppner
- Department of Neuropathology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin
- Roland Eils
- Center for Digital Health, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Marcus A. Mall
- German Center for Lung Research (DZL), associated partner site
- J. Brent Richards
- McGill Genome Centre, McGill University
- Leif-Erik Sander
- Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH)
- Irina Lehmann
- Molecular Epidemiology Unit, Center for Digital Health, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Sören Lukassen
- Center for Digital Health, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge
- Christian Conrad
- Center for Digital Health, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- Claudia Langenberg
- Computational Medicine, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
- DOI
- https://doi.org/10.1038/s41467-022-31999-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Genetic factors have been found to be associated with severe COVID-19. Here, the authors integrated genomic, proteomic, and single-cell data to identify ELF5 as a candidate risk gene with a possible role in respiratory epithelial cells, which are targeted by SARS-CoV-2.
