Dental manifestations of hypophosphatasia in children and the effects of enzyme replacement therapy on dental status: A series of clinical cases

Abstract

Abstract The most frequent dental signs of hypophosphatasia in children are premature loss of primary teeth, decrease in height of alveolar bone, and malocclusions. Enzyme replacement therapy with Asfotase alfa might be associated with stabilization of dental status.

Keywords

• asfotase alfa
• dental signs
• enzyme replacement therapy
• hypophosphatasia
• premature loss of primary teeth