Efficacy of clobetasol propionate (0.05%), amlexanox (5%), and triamcinolone acetonide (0.1%) in the treatment of oral lichen planus

Abstract

Objectives: This study aimed to compare the efficiencies of 0.05% clobetasol propionate, 0.1% triamcinolone acetonide, and 5% amlexanox in the management of oral lichen planus (OLP). Material and Method: A total of 120 patients diagnosed with oral lichen planus were equally divided into three groups and treated with 0.05% clobetasol propionate (group A), 0.1% triamcinolone acetonide (group B), and 5% amlexanox (group C) topical medicaments. The patients were evaluated for pain using the visual analog scale (VAS) and erosive lesion. Results: There was a statistically significant decrease in the VAS pain scale score from day 1 to day 15 in all of the tested groups. There was also a reduction in the erosive area on the right and left buccal mucosa on the 15th day with all three tested drugs. Triamcinolone acetonide (0.1%) was effective in reducing the erosive lesions on buccal mucosa when compared with 0.05% clobetasol propionate and 5% amlexanox. Conclusion: Clobetasol propionate, triamcinolone acetonide, and amlexanox were effective in treating OLP patients.

Keywords

• erosive
• management
• mucosa
• oral lichen planus
• visual analog scale