Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34
<sup>+</sup>
Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome

Nicole L. Diggins; Lindsey B. Crawford; Meaghan H. Hancock; Jennifer Mitchell; Jay A. Nelson

doi:10.1128/mBio.00621-21

mBio (Apr 2021)

Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34 <sup>+</sup> Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome

Nicole L. Diggins,
Lindsey B. Crawford,
Meaghan H. Hancock,
Jennifer Mitchell,
Jay A. Nelson

Affiliations

Nicole L. Diggins: ORCiD; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
Lindsey B. Crawford: ORCiD; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
Meaghan H. Hancock: ORCiD; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
Jennifer Mitchell: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
Jay A. Nelson: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA

DOI: https://doi.org/10.1128/mBio.00621-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Each herpesvirus family establishes latency in a unique cell type. Since herpesviruses genomes are maintained as episomes, the viruses need to devise mechanisms to retain the latent genome during cell division.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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