Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia

Zain M. Virk, MD; T. Lee Richardson, Jr., MD; Joseph F. Nowatzke, MD; Asad Ullah, MD; Dawn M. Pedrotty, MD; M. Benjamin Shoemaker, MD, MSCI; Arvindh Kanagasundram, MD; Dan M. Roden, MD; William G. Stevenson, MD

JACC: Case Reports (Jun 2023)

Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia

Zain M. Virk, MD,
T. Lee Richardson, Jr., MD,
Joseph F. Nowatzke, MD,
Asad Ullah, MD,
Dawn M. Pedrotty, MD,
M. Benjamin Shoemaker, MD, MSCI,
Arvindh Kanagasundram, MD,
Dan M. Roden, MD,
William G. Stevenson, MD

Affiliations

Zain M. Virk, MD: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA
T. Lee Richardson, Jr., MD: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA; Address for correspondence: Dr Tadarro Lee Richardson Jr, Vanderbilt University Medical Center, 2220 Pierce Avenue, 282 Preston Research Building, Nashville, Tennessee 37202, USA.
Joseph F. Nowatzke, MD: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA
Asad Ullah, MD: Vanderbilt University Medical Center, Department of Pathology, Nashville, Tennessee, USA
Dawn M. Pedrotty, MD: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA
M. Benjamin Shoemaker, MD, MSCI: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA
Arvindh Kanagasundram, MD: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA
Dan M. Roden, MD: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA
William G. Stevenson, MD: Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA

Journal volume & issue: Vol. 16
p. 101878

Abstract

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Rare variants in TTN are the most common monogenic cause of early-onset atrial fibrillation and dilated cardiomyopathy. Whereas cardiac sarcoidosis is very underdiagnosed, a common presentation can be ventricular arrhythmias. This report presents a patient with a likely pathogenic TTN variant and cardiac sarcoidosis. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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