Post-surgical wireless monitoring of arterial health progression
Sara R.A. Ruth,
Min-gu Kim,
Hiroki Oda,
Zhen Wang,
Yasser Khan,
James Chang,
Paige M. Fox,
Zhenan Bao
Affiliations
Sara R.A. Ruth
Department of Chemical Engineering, Stanford University, Stanford, CA, USA
Min-gu Kim
Department of Chemical Engineering, Stanford University, Stanford, CA, USA
Hiroki Oda
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA; Division of Plastic Surgery, Veterans Affairs Palo Alto, Palo Alto, CA, USA
Zhen Wang
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA; Division of Plastic Surgery, Veterans Affairs Palo Alto, Palo Alto, CA, USA
Yasser Khan
Department of Chemical Engineering, Stanford University, Stanford, CA, USA
James Chang
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA; Division of Plastic Surgery, Veterans Affairs Palo Alto, Palo Alto, CA, USA
Paige M. Fox
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA; Division of Plastic Surgery, Veterans Affairs Palo Alto, Palo Alto, CA, USA; Corresponding author
Zhenan Bao
Department of Chemical Engineering, Stanford University, Stanford, CA, USA; Corresponding author
Summary: Early detection of limb ischemia, strokes, and heart attacks may be enabled via long-term monitoring of arterial health. Early stenosis, decreased blood flow, and clots are common after surgical vascular bypass or plaque removal from a diseased vessel and can lead to the above diseases. Continuous arterial monitoring for the early diagnosis of such complications is possible by implanting a sensor during surgery that is wirelessly monitored by patients after surgery. Here, we report the design of a wireless capacitive sensor wrapped around the artery during surgery for continuous post-operative monitoring of arterial health. The sensor responds to diverse artery sizes and extents of occlusion in vitro to at least 20 cm upstream and downstream of the sensor. It demonstrated strong capability to monitor progression of arterial occlusion in human cadaver and small animal models. This technology is promising for wireless monitoring of arterial health for pre-symptomatic disease detection and prevention.
