Novel Coronavirus disease 2019 (nCOVID-19) a global pandemic is an ever-remaining threat for patients with Diabetic Mellites (DM). Herein, we have tried to provide brief insight to critically analyze the reasons causing the severity of Coronavirus disease (COVID-19) in patients diagnosed with DM. This, mini review highlights the key investigations starting from binding of COVID-19 at the cellular surface to create sever infection or even death in DM patients. The study further suggested to pay urgent attention towards stabilization of deadly immune response arises as a result of COVID-19. We hope the highlighted investigation will help the researchers to understand and develop a road map to deal DM patients infected with COVID-19 to minimize the severity rate.