Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Zhiwei Shao; Sheng Tu; Anwen Shao

doi:10.3389/fphar.2019.01079

Frontiers in Pharmacology (Sep 2019)

Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Zhiwei Shao,
Sheng Tu,
Anwen Shao

Affiliations

Zhiwei Shao: Department of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Sheng Tu: Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Anwen Shao: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

DOI: https://doi.org/10.3389/fphar.2019.01079
Journal volume & issue: Vol. 10

Abstract

Read online

Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury. The mechanism of injury after ICH is very complicated and has not yet been illuminated. This review discusses some key pathophysiology mechanisms in ICH such as oxidative stress (OS), inflammation, iron toxicity, and thrombin formation. The corresponding therapeutic targets and therapeutic strategies are also reviewed.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

Keywords