Nature Communications (May 2022)

Catalytic asymmetric Tsuji–Trost α−benzylation reaction of N-unprotected amino acids and benzyl alcohol derivatives

  • Jian-Hua Liu,
  • Wei Wen,
  • Jian Liao,
  • Qi-Wen Shen,
  • Yao Lin,
  • Zhu-Lian Wu,
  • Tian Cai,
  • Qi-Xiang Guo

DOI
https://doi.org/10.1038/s41467-022-30277-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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The catalytic asymmetric benzylations of prochiral nucleophiles are very limited. Here, the authors disclose an asymmetric α−benzylation of N-unprotected amino acids with benzyl alcohol derivatives by a chiral aldehyde-involved catalytic system.