Nature Communications (May 2022)
Catalytic asymmetric Tsuji–Trost α−benzylation reaction of N-unprotected amino acids and benzyl alcohol derivatives
Abstract
The catalytic asymmetric benzylations of prochiral nucleophiles are very limited. Here, the authors disclose an asymmetric α−benzylation of N-unprotected amino acids with benzyl alcohol derivatives by a chiral aldehyde-involved catalytic system.