Frontiers in Pediatrics (Jul 2021)

Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female

  • Prasanna Venkatesh Ramachandran,
  • Prasanna Venkatesh Ramachandran,
  • Prasanna Venkatesh Ramachandran,
  • C. Mary Healy,
  • C. Mary Healy,
  • Elton M. Lambert,
  • Elton M. Lambert,
  • Deyanara Guerra,
  • Choladda V. Curry,
  • Choladda V. Curry,
  • Tiphanie P. Vogel,
  • Tiphanie P. Vogel

DOI
https://doi.org/10.3389/fped.2021.674317
Journal volume & issue
Vol. 9

Abstract

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Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophilia and highly elevated IgE levels. Laboratory and histopathologic evaluation revealed an unlikely diagnosis of Kimura Disease. We discuss the differential diagnosis of a neck mass with prominent eosinophils on histology, and review support for T-helper type 2 (Th2) cell activation and hyper-IgE in Kimura Disease.

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