Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans

Ahmed M. Moustafa; Senthil Kumar Velusamy; Lidiya Denu; Apurva Narechania; Daniel H. Fine; Paul J. Planet

doi:10.1128/mBio.03581-20

mBio (Apr 2021)

Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans

Ahmed M. Moustafa,
Senthil Kumar Velusamy,
Lidiya Denu,
Apurva Narechania,
Daniel H. Fine,
Paul J. Planet

Affiliations

Ahmed M. Moustafa: ORCiD; Division of Pediatric Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Senthil Kumar Velusamy: Department of Oral Biology, Rutgers School of Dental Medicine, Newark, New Jersey, USA
Lidiya Denu: Division of Pediatric Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Apurva Narechania: Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York, USA
Daniel H. Fine: Department of Oral Biology, Rutgers School of Dental Medicine, Newark, New Jersey, USA
Paul J. Planet: ORCiD; Division of Pediatric Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

DOI: https://doi.org/10.1128/mBio.03581-20
Journal volume & issue: Vol. 12, no. 2

Abstract

Read online

There has been considerable interest in the impact of short-chain fatty acids (SCFAs) on inflammatory effects related to the microbiome. Here, we present evidence that SCFAs may also be important in disease by providing an energy source or disease-associated cue for colonizing pathogens.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal