Nature Communications (Feb 2021)
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity
- Nicolas Huot,
- Philippe Rascle,
- Caroline Petitdemange,
- Vanessa Contreras,
- Christina M. Stürzel,
- Eduard Baquero,
- Justin L. Harper,
- Caroline Passaes,
- Rachel Legendre,
- Hugo Varet,
- Yoann Madec,
- Ulrike Sauermann,
- Christiane Stahl-Hennig,
- Jacob Nattermann,
- Asier Saez-Cirion,
- Roger Le Grand,
- R. Keith Reeves,
- Mirko Paiardini,
- Frank Kirchhoff,
- Beatrice Jacquelin,
- Michaela Müller-Trutwin
Affiliations
- Nicolas Huot
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Philippe Rascle
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Caroline Petitdemange
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Vanessa Contreras
- CEA-Université Paris Sud-Inserm, U1184, IDMIT Department, IBFJ
- Christina M. Stürzel
- Ulm University Medical Center
- Eduard Baquero
- Institut Pasteur, Unité de Virologie Structurale
- Justin L. Harper
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Caroline Passaes
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Rachel Legendre
- Bioinformatics and Biostatistics Hub, Department of Computational Biology, Institut Pasteur
- Hugo Varet
- Biomics Platform, Center for Technological Resources and Research (C2RT), Institut Pasteur
- Yoann Madec
- Institut Pasteur; Epidemiology of Emerging Diseases Unit
- Ulrike Sauermann
- Deutsches Primatenzentrum - Leibniz Institut für Primatenforschung
- Christiane Stahl-Hennig
- Deutsches Primatenzentrum - Leibniz Institut für Primatenforschung
- Jacob Nattermann
- Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Germany; German Center for Infection Research (DZIF)
- Asier Saez-Cirion
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Roger Le Grand
- CEA-Université Paris Sud-Inserm, U1184, IDMIT Department, IBFJ
- R. Keith Reeves
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Mirko Paiardini
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Frank Kirchhoff
- Ulm University Medical Center
- Beatrice Jacquelin
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Michaela Müller-Trutwin
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- DOI
- https://doi.org/10.1038/s41467-021-21402-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
NK cells control SIV infection in secondary lymphoid tissues in the natural host that typically doesn’t progress toward disease. Here the authors show that this control is associated with terminal NK cell differentiation and improved MHC-E-dependent activity lacking in pathogenic SIV infection.
