A Review of Atypical Cutaneous Histological Manifestations of Herpes Zoster
Maged Daruish,
Gerardo Cazzato,
Dorota Markiewicz,
Saleem Taibjee,
Francesco Fortarezza,
Eduardo Calonje
Affiliations
Maged Daruish
Department of Histopathology, Dorset County Hospital NHS Foundation Trust, London DT1 2JY, UK
Gerardo Cazzato
Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, Italy
Dorota Markiewicz
Department of Dermatopathology, Guy’s and St Thomas’ NHS Foundation Trust, London DT1 2JY, UK
Saleem Taibjee
Department of Histopathology, Dorset County Hospital NHS Foundation Trust, London DT1 2JY, UK
Francesco Fortarezza
Surgical Pathology and Cytopathology Unit, University Hospital of Padova, 35100 Padova, Italy
Eduardo Calonje
Department of Dermatopathology, Guy’s and St Thomas’ NHS Foundation Trust, London DT1 2JY, UK
The clinical and histopathological features of herpes zoster (HZ) are usually straightforward. Atypical histological presentations, in the absence of the classical viral cytopathic changes, are well documented and can make the diagnosis of HZ extremely difficult. Herein, we review the existing literature on atypical cutaneous histological manifestations of the disease, with emphasis on the subtle clues, use of immunohistochemistry, and potential pitfalls.
