Clinical-functional and molecular characteristics of comorbid pathology (vibration disease combined with arterial hypertension)

Abstract

Purpose of the study. Based on the assessment of endothelial and hemostasiological parameters, to study the possibilities of early diagnosis of vascular disorders in case of vibration disease in combination with arterial hypertension. Material and methods. 253 patients with vibration disease in combination with arterial hypertension were examined in the conditions of the regional center of occupational pathology based on a specialized department of occupational pathology. The indicators of systemic, vascular-platelet, plasma-coagulation hemostasis, the state of markers of endothelial cell hemostasis are considered; platelet aggregation activity was determined; the study of adhesion molecules, the functional state of the endothelium. Results. Endothelial dysfunction in vibration disease in combination with arterial hypertension is characterized by increase of content of signaling molecules sPECAM-1, sVCAM-1 and sP-selektin, level of endothelin-1 in combination with increased production of vascular endothelial growth factor and transforming growth factor; endothelial markers are associated with the frequency of unfavorable polymorphic variants of genes; systemic hemostasis is characterized by an increase in the level of thrombospondin and thrombomodulin, platelet growth factor in conditions of a decrease in plasminogen activity, an increase in the concentration of α2-macroglobulin and fibrin decay products; identified early endothelial-hemostasiological markers of vascular disorders. Conclusions. As an early diagnosis of vascular disorders in vibration disease in combination with arterial hypertension, it is advisable to use early endothelial-hemostasiological markers of vascular disorders: content of inducible NO synthase, vascular endothelial growth factor, transforming growth factor β1, adhesive molecule, platelet growth factor BB, thrombospondin and fibrinopeptide A index, plasminogen activity, polymorphism of plasminogen, endothelial NO synthase, endothelin-1 and transforming growth factor β1 genes.

Keywords

• nutritional status
• molecular mediators
• functional markers
• vibration disease
• arterial hypertension
• comorbidity