A SEQUENTIAL DUAL CLEAVAGE OF THE ARYLSULFAMATE LINKER TO PROVIDE BOTH SULFAMATE AND PHENOL DERIVATIVES

Abstract

Tyramine sulfamate was linked to the trityl chloride resin and this polymeric support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split) two types of compounds (phenol and arylsulfamate derivatives), which are therapeutically attractive types of compounds.

Keywords

• solid-phase synthesis
• linker
• sulfamate
• phenol
• library