Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy

• Mi Zhou,
• Xiaoming Liu,
• Jiawen Zhang,
• Carson A Wills,
• Longgui Chen,
• Yuanjun Zhao,
• Jeffrey M Sundstrom,
• Todd Schell,
• Vladimir S Spiegelman,
• Megan M Young,
• Hong-Gang Wang

Affiliations

Mi Zhou

PhD student

Xiaoming Liu

1Human Genetics Center and Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, Texas, USA

Jiawen Zhang

Department of Obstetrics and Gynecology, Shanghai Tenth People`s Hospital, Tongji University; and

Carson A Wills

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

Longgui Chen

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

Yuanjun Zhao

Department of Ophthalmology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

Jeffrey M Sundstrom

Department of Ophthalmology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

Todd Schell

Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

Vladimir S Spiegelman

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

Megan M Young

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

Hong-Gang Wang

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA