Nilotinib-Induced Elephantine Psoriasis In a Patient With Chronic Myeloid Leukemia: A Rare Case Report and Literature Review

Seyedeh Fatemeh Sadatmadani; Zahra Malakoutikhah; Fatemeh Mohaghegh; Mohammadsaleh Peikar; Mahdi Saboktakin

Current Therapeutic Research (Jan 2022)

Nilotinib-Induced Elephantine Psoriasis In a Patient With Chronic Myeloid Leukemia: A Rare Case Report and Literature Review

Seyedeh Fatemeh Sadatmadani,
Zahra Malakoutikhah,
Fatemeh Mohaghegh,
Mohammadsaleh Peikar,
Mahdi Saboktakin

Affiliations

Seyedeh Fatemeh Sadatmadani: Medical Doctor, Skin Disease and Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Zahra Malakoutikhah: Medical Doctor, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Fatemeh Mohaghegh: Assistant Professor of Dermatopathology, Skin Disease and Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Address correspondence to: Fatemeh Mohaghegh, Assistant Professor of Dermatopathology, Skin Disease and Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Hazarjerib Street, Isfahan, Iran.
Mohammadsaleh Peikar: Assistant Professor of Hematology & Oncology, Department of Hematology and Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mahdi Saboktakin: Assistant Professor of Dermatopathology, Skin Disease and Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Address correspondence to: Fatemeh Mohaghegh, Assistant Professor of Dermatopathology, Skin Disease and Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Hazarjerib Street, Isfahan, Iran.

Journal volume & issue: Vol. 96
p. 100676

Abstract

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ABSTRACT: Tyrosine kinase inhibitors are anticancer drugs that disrupt signal transduction pathways in protein kinases by different mechanisms. This group of pharmacologic agents has significantly improved the outcome of patients with chronic myeloid leukemia. However, their effect is not limited to cancer cells, and various complications, particularly cutaneous reactions, have been reported. We report a very rare case of a 35-year-old female with a history of chronic myeloid leukemia who presented with elephantine psoriasis after the treatment with nilotinib.Conclusions: This case highlights a critical side effect of tyrosine kinase inhibitors. Awareness of this subject can be useful for better management of similar patients.

Published in Current Therapeutic Research

ISSN: 0011-393X (Print); 1879-0313 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/current-therapeutic-research/

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