Quinacetophenone: A simple precursor to privileged organic motifs

Abstract

This review presents the chemistry of quinacetophenone and its utility as an easily accessible building block for the synthesis of various advantageous organic compounds. This versatile precursor can be easily synthesized via different synthetic methodologies such as Friedel–Crafts acetylation, Fries rearrangement and Hoesch reaction. Based upon its inherent chemical reactivity, the title compound has been utilized to construct various organic molecules such as chalcones, chromones, flavonoids, coumarins, quinones and azoles including various naturally and biologically active compounds. Keywords: Hydroxyacetophenone, Chalcone, Chromone, Flavone, Chromanone, Coumarin