Nature Communications (Oct 2021)
Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus
- Jennifer A. E. Payne,
- Julien Tailhades,
- Felix Ellett,
- Xenia Kostoulias,
- Alex J. Fulcher,
- Ting Fu,
- Ryan Leung,
- Stephanie Louch,
- Amy Tran,
- Severin A. Weber,
- Ralf B. Schittenhelm,
- Graham J. Lieschke,
- Chengxue Helena Qin,
- Daniel Irima,
- Anton Y. Peleg,
- Max J. Cryle
Affiliations
- Jennifer A. E. Payne
- Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University
- Julien Tailhades
- Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University
- Felix Ellett
- BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School
- Xenia Kostoulias
- Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
- Alex J. Fulcher
- Monash Micro Imaging, Monash University
- Ting Fu
- Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University
- Ryan Leung
- Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University
- Stephanie Louch
- Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University
- Amy Tran
- Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University
- Severin A. Weber
- Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University
- Ralf B. Schittenhelm
- Monash Proteomics and Metabolomics Facility, Monash University
- Graham J. Lieschke
- Australian Regenerative Medicine Institute, Monash University
- Chengxue Helena Qin
- Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University
- Daniel Irima
- BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School
- Anton Y. Peleg
- Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
- Max J. Cryle
- Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University
- DOI
- https://doi.org/10.1038/s41467-021-26244-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Antibiotic resistance in Staphylococcus aureus is associated with reduced neutrophil recruitment. Here, Payne et al. link formylated peptides, which act as chemoattractants for neutrophils, with the antibiotic vancomycin and show that these hybrid compounds improve clearance of S. aureus by neutrophils.
