A human antibody against Zika virus crosslinks the E protein to prevent infection

S. Saif Hasan; Andrew Miller; Gopal Sapparapu; Estefania Fernandez; Thomas Klose; Feng Long; Andrei Fokine; Jason C. Porta; Wen Jiang; Michael S. Diamond; James E. Crowe Jr.; Richard J. Kuhn; Michael G. Rossmann

doi:10.1038/ncomms14722

Nature Communications (Mar 2017)

A human antibody against Zika virus crosslinks the E protein to prevent infection

S. Saif Hasan,
Andrew Miller,
Gopal Sapparapu,
Estefania Fernandez,
Thomas Klose,
Feng Long,
Andrei Fokine,
Jason C. Porta,
Wen Jiang,
Michael S. Diamond,
James E. Crowe Jr.,
Richard J. Kuhn,
Michael G. Rossmann

Affiliations

S. Saif Hasan: Department of Biological Sciences, Purdue University
Andrew Miller: Department of Biological Sciences, Purdue University
Gopal Sapparapu: Department of Pediatrics, Vanderbilt University Medical Center
Estefania Fernandez: Department of Pathology & Immunology, Washington University School of Medicine
Thomas Klose: Department of Biological Sciences, Purdue University
Feng Long: Department of Biological Sciences, Purdue University
Andrei Fokine: Department of Biological Sciences, Purdue University
Jason C. Porta: Department of Biological Sciences, Purdue University
Wen Jiang: Department of Biological Sciences, Purdue University
Michael S. Diamond: Department of Pathology & Immunology, Washington University School of Medicine
James E. Crowe Jr.: Department of Pediatrics, Vanderbilt University Medical Center
Richard J. Kuhn: Department of Biological Sciences, Purdue University
Michael G. Rossmann: Department of Biological Sciences, Purdue University

DOI: https://doi.org/10.1038/ncomms14722
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 6

Abstract

Read online

The human monoclonal antibody ZIKV-117 has demonstrated therapeutic potential against Zika while showing no cross-reactivity to other flaviviruses. Here the authors present a cryo-EM structure of the ZIKV strain H/PF/2013 in complex with the ZIKV-117 Fab, shedding light on its neutralization mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal