The Spectrum of Causative Agents of Complicated Abdominal Infections in Surgical Patients

Abstract

RELEVANCE Treatment of patients with complicated abdominal infections (AI) is still a difficult task, as evidenced by high mortality rates. THE AIM OF THE STUDY is to analyze the results of microbiological investigations of patients with advanced diffuse peritonitis who were treated in the surgical department of the emergency hospital. MATERIAL AND METHODS In this study, the main pathogens of advanced peritonitis were identified in 69 patients (the average age of patients was 64±17 years). The cause of peritonitis in the absolute majority of cases (94%) was a perforation of the gastrointestinal tract. A study of various types of clinical material was carried out: blood — 143 samples, urine — 125 samples, bronchoalveolar lavage — 119 samples and 130 samples of wound discharge. 260 strains of microorganisms were isolated. RESULTS The predominance of the Enterobacteriacea species (K. pneumoniae and E. coli), non-fermenting bacteria (Acinetobacter spp.) as well as the increasing role of Enterococcus spp. and Staphylococcus spp. (S. aureus and CNS) were found. Multidrug-resistant strains dominated among the identified pathogens. CONCLUSION The obtained data on the structure of pathogens of complicated abdominal infection confirm global trends. In order to develop new treatment methods for complicated AI, one of the possible solutions may be the use of human microbial ecology approaches.

Keywords

• pathogens of complicated abdominal infection
• enterobacteriaceae species
• acinetobacter spp.
• staphylococcus spp.
• multidrug-resistant strains