Multiplexed live-cell profiling with Raman probes

Chen Chen; Zhilun Zhao; Naixin Qian; Shixuan Wei; Fanghao Hu; Wei Min

doi:10.1038/s41467-021-23700-0

Nature Communications (Jun 2021)

Multiplexed live-cell profiling with Raman probes

Chen Chen,
Zhilun Zhao,
Naixin Qian,
Shixuan Wei,
Fanghao Hu,
Wei Min

Affiliations

Chen Chen: Department of Chemistry, Columbia University
Zhilun Zhao: Department of Chemistry, Columbia University
Naixin Qian: Department of Chemistry, Columbia University
Shixuan Wei: Department of Chemistry, Columbia University
Fanghao Hu: Department of Chemistry, Columbia University
Wei Min: Department of Chemistry, Columbia University

DOI: https://doi.org/10.1038/s41467-021-23700-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Currently relatively few functional probes for Raman-based live-cell profiling exist. Here the authors build on their previous ultra-bright Raman dots to devise a 14-plexed Raman probe panel to quantify cell surface proteins, endocytosis activities and metabolic dynamics of single live cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal