International Journal of General Medicine (Dec 2020)
Is Pathologic Complete Response the Surrogate in Primary Gastric Angiosarcoma Undergoing Doxorubicin-Based Neoadjuvant Chemotherapy? A Case Report
Abstract
Chun-Hui Zheng,1,2 Yang Wang,3 Ting-Ting Liu,4 Xiao-Yan Ding,5 Jian-Jun Qu,2,* Zhi-De Su6,* 1Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Oncology Surgery, Weifang People’s Hospital, Weifang, Shandong, People’s Republic of China; 3Department of General Surgery, Weifang People’s Hospital, Weifang, Shandong, People’s Republic of China; 4Department of Breast Surgery, Tai’an Central Hospital, Tai’an, Shandong, People’s Republic of China; 5Department of Laboratory Medicine, Weifang Medical University, Weifang, Shandong, People’s Republic of China; 6Department of Pharmacy, Weifang People’s Hospital, Weifang, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-Jun QuDepartment of Oncology Surgery, Weifang People’s Hospital, 151 Guangwen Street, Weifang, Shandong 261041, People’s Republic of ChinaEmail [email protected] SuDepartment of Pharmacy, Weifang People’s Hospital, 151 Guangwen Street, Weifang, Shandong 261041, People’s Republic of ChinaEmail [email protected]: Angiosarcoma is a malignant tumor with low incidence. Especially in the advanced tumors, there is still a lack of knowledge of evidence-based medicine.Case Presentation: We report a case of a 55-year-old woman with abdominal pain of 2 months of duration, which had increased in severity for 2 weeks prior to the presentation. The diagnosis is primary gastric angiosarcoma. We performed multiple disciplinary team (MDT), and doxorubicin-based neoadjuvant chemotherapy (NAC) was proposed. After two cycles of NAC, a computed tomography (CT) scan showed complete regression compared with the previous scan. An open surgery was done, and surgical specimens were confirmed as a pathological complete response (PCR) by pathological and immunohistochemical examination, but unfortunately, the patient suffered a relapse after the surgery in 3 months.Conclusion: Repeated endoscopic biopsy and biopsy specimen examinations can improve accuracy in diagnosis. It seems that NAC could be a candidate for advanced primary gastric angiosarcomas. But after the rapid relapse, we are wondering whether pathologic complete response is the surrogate in primary gastric angiosarcoma undergoing NAC.Keywords: gastric angiosarcoma, stomach, neoadjuvant chemotherapy, pathologic complete response
