Relationship between gut microbiota and circulating metabolites in population-based cohorts

Dina Vojinovic; Djawad Radjabzadeh; Alexander Kurilshikov; Najaf Amin; Cisca Wijmenga; Lude Franke; M. Arfan Ikram; Andre G. Uitterlinden; Alexandra Zhernakova; Jingyuan Fu; Robert Kraaij; Cornelia M. van Duijn

doi:10.1038/s41467-019-13721-1

Nature Communications (Dec 2019)

Relationship between gut microbiota and circulating metabolites in population-based cohorts

Dina Vojinovic,
Djawad Radjabzadeh,
Alexander Kurilshikov,
Najaf Amin,
Cisca Wijmenga,
Lude Franke,
M. Arfan Ikram,
Andre G. Uitterlinden,
Alexandra Zhernakova,
Jingyuan Fu,
Robert Kraaij,
Cornelia M. van Duijn

Affiliations

Dina Vojinovic: Department of Epidemiology, Erasmus MC, University Medical Center
Djawad Radjabzadeh: Department of Internal Medicine, Erasmus MC, University Medical Center
Alexander Kurilshikov: University of Groningen, University Medical Center Groningen, Department of Genetics
Najaf Amin: Department of Epidemiology, Erasmus MC, University Medical Center
Cisca Wijmenga: University of Groningen, University Medical Center Groningen, Department of Genetics
Lude Franke: University of Groningen, University Medical Center Groningen, Department of Genetics
M. Arfan Ikram: Department of Epidemiology, Erasmus MC, University Medical Center
Andre G. Uitterlinden: Department of Epidemiology, Erasmus MC, University Medical Center
Alexandra Zhernakova: University of Groningen, University Medical Center Groningen, Department of Genetics
Jingyuan Fu: University of Groningen, University Medical Center Groningen, Department of Genetics
Robert Kraaij: Department of Internal Medicine, Erasmus MC, University Medical Center
Cornelia M. van Duijn: Department of Epidemiology, Erasmus MC, University Medical Center

DOI: https://doi.org/10.1038/s41467-019-13721-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 7

Abstract

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Here, the authors provide an in-depth study of the metabolome in two large population-based prospective cohorts and identify 32 microbial traits associated with various metabolic biomarkers and specific lipoprotein subfractions, providing insights into the role of microbiota in influencing host lipid levels.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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