E-Journal of Chemistry (Jan 2006)

RP-HPLC Determination of Raloxifene in Pharmaceuticl Tablets

  • P. Venkata Reddy,
  • B. Sudha Rani,
  • G. Srinu Babu,
  • J. V. L. N. Seshagiri Rao

DOI
https://doi.org/10.1155/2006/713569
Journal volume & issue
Vol. 3, no. 1
pp. 60 – 64

Abstract

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A reverse phase HPLC method is developed for the determination of Raloxifene in pharmaceutical dosage forms. Chromatography was carried out on an inertsil C18 column using a mixture of acetonitrile and phosphate buffer (30:70 v/v) as the mobile phase at a flow rate of 1 mL/min. Detection was carried out at 290 nm .The retention time of the drug was 10.609 min. The method produced linear responses in the concentration range of 0.5-200 µg/mL of Raloxifene. The method was found to be applicable for determination of the drug in tablets.