Nucleostemin: A new trailblazer in oral squamous cell carcinoma – A brief review

Abstract

Nucleostemin (NS) is a guanine nucleotide binding protein like 3 (GNLP 3) found in the nucleolus in neuroepithelial stem cells, embryonic stem cells and in cancer stem cells. It is observed to be an initiator for uncontrolled cellular proliferation that is responsible for cancer progression by interaction with p53, mouse double minute 2 (MDM2) and cell-cycle.

Keywords

• cell cycle
• malignant transformation
• nucleostemin
• p53