A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging

Takahiro Kuchimaru; Satoshi Iwano; Masahiro Kiyama; Shun Mitsumata; Tetsuya Kadonosono; Haruki Niwa; Shojiro Maki; Shinae Kizaka-Kondoh

doi:10.1038/ncomms11856

Nature Communications (Jun 2016)

A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging

Takahiro Kuchimaru,
Satoshi Iwano,
Masahiro Kiyama,
Shun Mitsumata,
Tetsuya Kadonosono,
Haruki Niwa,
Shojiro Maki,
Shinae Kizaka-Kondoh

Affiliations

Takahiro Kuchimaru: School of Life Science and Technology, Tokyo Institute of Technology
Satoshi Iwano: Graduate School of Informatics and Engineering, The University of Electro-Communications
Masahiro Kiyama: Graduate School of Informatics and Engineering, The University of Electro-Communications
Shun Mitsumata: School of Life Science and Technology, Tokyo Institute of Technology
Tetsuya Kadonosono: School of Life Science and Technology, Tokyo Institute of Technology
Haruki Niwa: Graduate School of Informatics and Engineering, The University of Electro-Communications
Shojiro Maki: Graduate School of Informatics and Engineering, The University of Electro-Communications
Shinae Kizaka-Kondoh: School of Life Science and Technology, Tokyo Institute of Technology

DOI: https://doi.org/10.1038/ncomms11856
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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D-luciferin is the standard bioluminescent substrate for in vitro and in vivo imaging. Here the authors introduce AkaLumine-HCl, a soluble luciferin analogue with a near-infrared emission maximum, which allows deep tissue imaging at lower concentrations than D-luciferin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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