Solid-phase synthesis of isoalloxazines using merrifield resin

Abstract

The reaction of Merrifield resin bound diamino compounds with alloxan monohydrate gave 7-resin bound 10-substituted isoalloxazines that were characterized by solid phase fluorescence and IR spectroscopy. The resin was cleaved by 40% aqueous HF/DMF to give 7-carboxy-10-substituted isoalloxazines that were characterized by UV-vis., IR, ¹H NMR, fluorescence and elemental analysis

Keywords

• isoalloxazines (or flavins)
• merrifield resin
• polymer-supported synthesis
• cyclocondensation
• alloxan monohydrate
• solid-state fluorescence