OncoTargets and Therapy (Nov 2019)

The Exosome And Breast Cancer Cell Plasticity

  • Mao X,
  • Jin F

Journal volume & issue
Vol. Volume 12
pp. 9817 – 9825

Abstract

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Xiaoyun Mao, Feng Jin Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of ChinaCorrespondence: Feng JinDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang City, Liaoning Province, People’s Republic of ChinaTel/Fax +86 24 83282618Email [email protected]: Cancer cell plasticity is the ability of cancer cells to reversibly interchange between distinct cell status, which plays a key role in cancer progression. Cancer cell plasticity is now known to be shaped by the secreted nanoparticles termed exosomes which transport proteins and lipids as well as nucleic acids. These aspects have emerged as key determinants of tumor progression and targeting, with approaches such as immunotherapy showing promise in the clinic. While significant strides have been made in this research area, some very interesting questions still warrant more and deeper investigation. We provide a review of the interplay between exosomes and breast cancer cell plasticity, and the potential implication in metastases and drug-resistance.Keywords: exosome, breast cancer, cancer cell plasticity

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