Data on the optimization of a GC–MS procedure for the determination of total plasma myo-inositol
Jin Guo,
Yingfei Shi,
Chengbao Xu,
Rugang Zhong,
Feng Zhang,
Bo Niu,
Jianhua Wang,
Ting Zhang
Affiliations
Jin Guo
Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China
Yingfei Shi
Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
Chengbao Xu
Chinese Academy of Inspection & Quarantine, Beijing 100023, China
Rugang Zhong
Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
Feng Zhang
Chinese Academy of Inspection & Quarantine, Beijing 100023, China
Bo Niu
Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China
Jianhua Wang
Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China; Corresponding authors at: Capital Institute of Pediatrics, Beijing 100020, China. Fax: +86 010 85631504.
Ting Zhang
Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China; Corresponding authors at: Capital Institute of Pediatrics, Beijing 100020, China. Fax: +86 010 85631504.
Myo-inositol (MI) is one of the stereoisomers of hexahydroxycyclohexane, which plays an important role in intracellular signal pathway. Derivatization is an indispensable step in both external and internal standard method during the chromatography-mass spectrometer (GC–MS) detection, as MI can’t be ionized directly. It is valuable to optimize the derivative process and the detection volume for clinical detection. This article contains optimization data related to research publication “Quantification of plasma myo-inositol using gas chromatography–mass spectrometry” [1]. Here we introduce the data on the optimized derivatization volume, temperature, duration and the detection volume. Keywords: Gas chromatography-mass spectrometry, Myo-inositol, Derivatives
